Candidate Endophenotypes for Genetic Studies of Suicidal Behavior
نویسندگان
چکیده
منابع مشابه
Candidate endophenotypes for genetic studies of suicidal behavior.
Twin, adoption, and family studies have established the heritability of suicide attempts and suicide. Identifying specific suicide diathesis-related genes has proven more difficult. As with psychiatric disorders in general, methodological difficulties include complexity of the phenotype for suicidal behavior and distinguishing suicide diathesis-related genes from genes associated with mood diso...
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While it is generally acknowledged that borderline personality disorder has a complex, multifactoral etiology with interacting genetic and environmental substrates, the specific genetic underpinnings of this disorder have not been extensively investigated. Family aggregation studies suggest the heritability for borderline personality disorder as a diagnosis, but the genetic basis for this disor...
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BACKGROUND Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia or alcohol dependence. Given the suicidal behavior heterogeneity and its hereditary complexity, the need to find demonstrable intermediate phenotypes that may make it possible to establish l...
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This article reviews the concept of an endophenotype, with particular reference to heritability as well as diagnostic specificity. An endophenotype need not be heritable, for example, the possible influence of in utero viral infections for schizophrenia. However, heritability is a useful characteristic for a potential endophenotype, as it can be studied in relation to a plausible candidate gene...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2009
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2008.11.021